#Hippocampus anatomy and function rat trial#

Giant вЂbrainsвЂ™ that ?lled air-conditioned rooms were shrunk into briefcases. Publisher: Springer Science & Business MediaДЇifty years ago, enthused by successes in creating digital computers and the DNA model of heredity, scientists were con?dent that solutions to the problems of und- standing biological intelligence and creating machine intelligence were within their grasp. mechanisms of hippocampal-cortical signalling for mnemonic function and behavior, we recorded ventral hippocampalВ . Hippocampal-Prefrontal Cortex System During Spatial Learning and Strategy Shifts in Rats Francesco P. The book collects evidence of various hippocampal functions in healthy and disordered brain. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. This book covers the topic of the hippocampus from various perspectives. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Spatial and nonspatial escape strategies in the Barnes maze. allocentric but preserved egocentric spatial learning in transgenic mice with impaired glucocorticoid receptor function. These results support the idea that BDNF and the Trk B receptor play an important role in spatial learning and memory. Administration of ANA-12 did not impair ratsвЂ™ ability to learn or perform the T-maze task, but it did cause dose-dependent decreases in their use of place strategies on the probe trial.

#Hippocampus anatomy and function rat trial#

After reaching criterion, the rats received a probe trial in which the two strategies were pitted against one another. Rats received 0.5 or 1.0 mg/kg ANA-12 or saline four hours before training on a T-maze task that could be solved using either a hippocampal-dependent place strategy or a striatum-dependent response strategy. The present study examined the role of BDNF in spatial learning by investigating the effects of ANA-12, a noncompetitive antagonist for the Trk B receptor, on spatial learning in a T-maze. Much of this evidence has been indirect, however, and relatively few behavioral studies have directly manipulated BDNF or the receptor that binds it, tropomyosin receptor kinase B (Trk B). Prior research has implicated brain-derived neurotropic factor (BDNF) in synaptic plasticity in the hippocampus and in forms of spatial learning and memory that depend on this brain system. *New material covers basal ganglia, cerebellum, prefrontal cortex, and fear conditioning *Additional information available on applied issues (i.e., degenerative disease, aging, and enhancement of memory) *Each chapter includes an outline to assist student understanding of challenging concepts *Four-color illustrations throughout The emphasis of each chapter will be the presentation of cutting-edge research on the topic, the development of a theoretical perspective, and providing an outline that will aid a student in understanding the most important concepts presented in the chapter. Including information from both animal and human studies, this book represents an up-to-date review of the most important concepts associated with the basic mechanism that support learning and memory, theoretical developments, use of computational models, and application to real world problems. As before, this second edition will discuss anatomy, development, systems, and models though the organization and content is substantially changed reflecting advances in the field. The first edition of Neurobiology of Learning and Memory was published in 1998 to rave reviews. INVOLVEMENT OF THE HIPPOCAMPUS IN SPATIAL LEARNING AND MEMORY A fundamental goal for research in the area of behavioralВ . But if the task can be solved using an alternative strategy, aged rats perform as well as do young rats (e.g.